Participate As a Dialysis Center

Participate As a
Dialysis Center

We are currently seeking additional dialysis centers to partner with in the HiLo study. HiLo is a large pragmatic study on how best to manage blood phosphate levels in patients on dialysis.

Interested?

What is the best blood level of phosphate for people with kidney failure on dialysis?

Is Your Dialysis Center
a Good fit for the
HiLo Study?

We are currently seeking additional dialysis centers to partner with in the HiLo study. HiLo is a large pragmatic study on how best to manage blood phosphate levels in patients on dialysis.Complete an interest survey if you would like to be considered as a participating dialysis center.

Study Overview

Hi arm

is considered the intervention strategy Goal: Titrate serum phosphate to ≥6.5 mg/dl

Lo arm

is considered the intervention strategy Goal: Titrate serum phosphate to ≥6.5 mg/dl

Site Selection Criteria

  • Reliable WiFi
  • Willing to have dialysis unit randomized to either Hi or Lo arm
  • Have a population of 60-180 patients

How HiLo is Pragmatic

Pragmatic

Based in "real world" practice and collects "real world" data

Multicenter

More than 100 outpatient HD facilities across US

Large

About 4400 patients in total for up to four years of follow-up

Cluster-randomized

Randomize entire dialysis facilities instead of individual patients

Open-label

Staff and participants will know what treatment they get

Outcomes trial

Compares "hard" clinical outcomes

  • Composite of all-cause mortality and all-cause hospitalization

"Guidelines for how best too manage phosphate levels are based on expert opinion rather than clinical trial results. For decades, we have thought it best to lower serum phasphate. Results from HiLo will help us understand if our approach is or is not helping patients"

 

Myles Wolf, MD, MMSc
HiLo Study Principal Investigator
Duke University Medical Center
Division of Nephrology

Contact the HiLo
StudyTeam

1-888-973-1596 (voice mail)

HiLo@duke.edu