What is the best blood level of phosphate for people with kidney failure on dialysis?
What is HILO?
HiLo is a clinical research
study on how best to manage blood phosphate levels in patients on dialysis. Researchers will compare how participants feel, how often they are hospitalized, and how long they live based on the level of phosphate in their blood.
Current guidelines for managing blood phosphate levels are based on expert opinion, not from results of clinical research. For years, doctors have thought that patients on dialysis would feel and do better if their blood phosphate level was lowered. However, this has never been studied in a formal clinical research study until now in HiLo.
The HiLo study is supported by the National Institute of Diabetes and Digestive and Kidney Diseases and is a demonstration project of the National Institutes of Health (NIH) Health Care Systems Research Collaboratory. Researchers from the Duke Clinical Research Institute will coordinate the operations and data functions of the study. The study will take place in outpatient dialysis centers that care for a substantial number of the U.S. dialysis population.
The HiLo study team consists of nephrologists, dietitians, facility managers, scientists, and clinical research professionals. HiLo is the first clinical research study that will provide evidence to inform guidelines for phosphate management. Results from HiLo have the potential to rapidly influence the care of kidney patients receiving dialysis.
Patient ambassadors from the American Association of Kidney Patients collaborate with HiLo study team members to provide the patient perspective. By sharing their personal experiences with dialysis and kidney disease, these patient ambassadors help improve the research experience for all HiLo study participants.
Research studies like HiLo cannot be done without participants who volunteer to be involved. Study participants in HiLo will contribute health information and other valuable data to help doctors know how best to manage blood phosphate levels for future kidney patients receiving dialysis.
“Guidelines for how best to manage phosphate levels are based on expert opinion rather than clinical trial results. For decades, we have thought it best to lower serum phosphate. Results from HiLo will help us understand if our approach is or is not helping patients.”
Myles Wolf, MD, HiLo Principal Investigator